Treatment Resistant Depression
We explore alternative option to SSRI or SNRI medications for treatment of Depression and Anxiety.
A substantial proportion of patients with MDD do not respond to current treatments, despite many antidepressant trials and augmentation strategies, up to ~20% of patients with MDD havetreatment-resistant depression. It means that depression and anxiety is not only a serototin deficiency. Medications that effect glutamate system and operate by blocking the N-methyl-D-aspartate (NMDA) glutamate receptor have shown effectiveness in treatment of depression. In addition, signs of bipolar depression or milder form of mood disorder is often not recognized leading to frequent treatment failure. Patients often report improvement in their symptoms initially with SSRIs, but overtime the effectiveness is reduced. There is also a tendency to prescribe SSRI or psychiatric medications long-term without attempts to lower the dose.
Dangers and Adverse effects associated with short-term and chronic use of SSRI and SNRI medications:
Extrapyramidal Reactions Associated with Serotonergic Antidepressants.
SSRI or SNRI discontinuation withdrawal syndrome
Drug-Induced Serotonin Syndrome
Burning paresthesia (tingling, numbness, and itching)
Increased risk for suicidality and aggression (particularly in children and teenagers)
Sexual side effects and weight gain
Emotional numbness (inability to cry, lack of sensitivity or experiencing feelings – could have an effect on a person’s ability to process emotions or traumatic events)
SSRI induced hypomanic and manic episode