There is growing evidence that the imbalance between oxidative stress and the antioxidant defense system may be associated with the development neuropsychiatric disorders, such as depression and anxiety. Major depression and anxiety are presently correlated with a lowered total antioxidant state and by an activated oxidative stress (OS) pathway. High stress environment, poor nutrition and environmental toxins are major causes of inflammation and mitochondrial dysfunction. Addressing nutritional deficiencies, dietary lifestyle, hormone and gastrointestinal imbalance, promoting exercise and modifying medications to facilitate neuroplasticity are key treatment options in improving mood disorders.
Balmus I.M., Ciobica A, Antioch J., Dobrin R. and Timofte D. April 2016. Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches. Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 3975101, 25 pages http://dx.doi.org/10.1155/2016/3975101